The following clinical studies, from the peer-reviewed literature detail the safety, efficacy and effectiveness of Topical Hyperbaric Oxygen therapy in treating and resolving a variety of ulcers.

"Does Topical Wound Oxygen (TWO2) Offer an Improved Outcome Over Conventional Compression Dressings (CCD) in the Management of Refractory Venous Ulcers (RVU)? A Parallel Observational Comparative Study", W. Tawfick a, S. Sultan, Eur J Vasc Endovasc Surg (2009) 38, 125-132

"Topical Wound Oxygen (two2™) Versus Conventional Compression Dressings in the Management of Refractory Non-healing Venous Ulcers; A Parallel Observational Pivotal Study" Wael Tawfic , Ireland Royal Academy of Medicine in Ireland, Irish Journal of Medical Science, Volume 176, Number 1, 2007 Supplement 2, 5th Annual Vascular Institute Symposium, Galway

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"Therapeutic value of hyperbaric oxygen in lower extremity ulcerations" Francis Rossi Royal Academy of Medicine in Ireland, Irish Journal of Medical Science, Volume 176, Number 1, 2007 Supplement 2, 5th Annual Vascular Institute Symposium, Galway

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Sacral Unit Case Study: Use of Topical Hyperbaric Oxygen for Treatment of Chronic Woulnds in Long-Term Care Facilities. Edsberg LE, Brogan MS, Jaynes CD, Fries K. Natural and Health Sciences Research Center, Daemen College Ostomy Wound Management. April, 2003

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Topical hyperbaric oxygen and electrical stimulation: exploring potential synergy. Edsberg LE, Brogan MS, Jaynes CD, Fries K. Natural and Health Sciences Research Center, Daemen College Ostomy Wound Management. April, 2003

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Guo S., Counte M., Gillespie K., Schmitz H. Cost-Effectiveness of Adjunctive Hyperbaric Oxygen in the Treatment of Diabetic Ulcers International Journal of Technology Assessment in Health Care (2003), 19:4:731-737

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Baroni G, Porro T, Faglia E, et al. Hyperbaric oxygen in diabetic gangrene treatment. Diabetes Care. 1987;10:81-86.

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Scott G., Reeves R., Topical oxygen alters angiogenesis-related grwoth factor expression in chronic diabetic foot ulcers. Academic Poster

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Diamond E., Forst M., Hyman S. Scott R. The Effect of Hyperbaric Oxygen on Lower Extremity Journal of the American Podiatry Association - Volume 72 • Number 4, April 1982

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Rossi F. Elsinger E. Topical Hyperbaric Oxygen Therapy For Lower-Extremity Wound Care; An Overview Podiatry Management November 1997

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Topical Hyperbaric Oxygenation in the Treatment of Recalcitrant Open Wounds: A Clinical Report A. Valentino Upson Physical Therapy - Vol. 66 No. 9, September 1986

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Reducing Epibole Using Topical Hyperbaric Oxygen and Electrical Stimulation Laura E. Edsberg, PhD; Michael S. Brogan, MS, PT, CWS; C David Jaynes, PhD; and Kristin Fries, PhD Ostomy Wound Management - Vol. 48 Issue 4, April 2002

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Human Bite Infections of the Hand: Adjunct Treatment with Hyperbaric Oxygen William L. Lehman, Jr. MD, Wallace W. Jones, MD, Maria D. Allo, MD, Renner M. Johnston, MD, Peter L.J. McGanity, MD Infections in Surgery - June 1985

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Angiogenesis in Necrotic Ulcers Treated With Hyperbaric Oxygen Madalene C.Y. Heng, MD, FRACP, FACD; Judith Harker, PhD; George Crathy, MD; Charles Marshall, MD; Joselynn Brazier, MD; Socorro Sumampong, RN; Edna Paterno Gomez, RN Ostomy Wound Management - Volume 46, Issue 9, September 2000

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The Microclimate Chamber: The Effect of Continuous Topical Administration of 96% Oxygen and 75% Relative Humidity on the Healing Rate of Experimental Deep Burns THEODOR KAUFMAN, M.D., J. WESLEY ALEXANDER, M.D., Sc.D., PAUL NATHAN, PH.D., KIM A. BRACKETT, PH.D., AND BRUCE G. MACMILLAN, M.D. Journal of Trauma - Volume 23, Issue 9, September 1983

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Revisiting the essential role of oxygen in wound healing Gayle M. Goriillo, M.D., Chandan K. Sen, PhD. American Journal of Surgery - 186 (2003) 259-263

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Topical hyperbaric oxygen and low energy laser for the treatment of diabetic foot ulcers Z. Landau American Orthopedic Trauma Surgery - 1998-117:156-158

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Topical Oxygen Therapy Treatment of Extensive Leg and Foot Ulcers DANIEL R. IGNACIO, MD, ALFRED P. PAVOT, MD, RIDA N. AZER, MD LEONARD WISOTSKY, DPM Journal of the American Podiabic Medical Association - Volume 75, Number 4, April 1985

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Topical oxygen as an adjunct to wound healing: a clinical case series Loree K. Kalliainen, Gayle M. Gordillo, Richard Schlanger, Chandan K. Sen Pathophysiology 9 (2003) 81-87

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Topical Hyperbaric Therapy for Problem Skin Wounds Madalene C.Y. Heng, MB, FRACP, FACD Journal Dermatol Surg Oncol - 1993:19-784-793

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Topical Oxygen Promotes Healing of Leg Ulcers Stanley Olejniczak, M.D., Andrew Zletinski, M.D., Ph.D Medical Times - December 1976

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Original Two Article Upon Which This Equipment is a Direct Descendent

 

TOPICAL HYPERBARIC OXYGEN TREATMENT OF PRESSURE SORES AND SKIN ULCERS Boguslav H. Fischer, Institute of Rehabilitation Medicine, New York University Medical Center New York, New York The Journal of Dermatologic Surgery - Vol. 1 No. 3, October 1975

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TOPICAL HYPERBARIC OXYGEN TREATMENT OF PRESSURE SORES AND SKIN ULCERS Boguslav H. Fischer, Institute of Rehabilitation Medicine, New York University Medical Center New York, New York The Lancet, August 23, 1969

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